Target intelligence / Profile preview

Poly [ADP-ribose] Polymerase 7

Molecular classification: Enzyme, Mono(ADPr)-transferase

Overview

Poly [ADP-ribose] polymerase 7 (PARP7), also known as ARTD14 or TIPARP, is a mono-ADP-ribosyltransferase (MART) that plays roles in transcriptional regulation, immune response modulation, and cellular stress responses. It catalyzes mono(ADP)-ribosylation using NAD+ as a substrate and is predominantly nuclear. PARP7's role in cancer appears context-dependent, with evidence suggesting both tumor suppressor and promoter functions. Inhibitors targeting PARP7 are being explored for their potential anticancer effects.

Other names: ARTD14TIPARP

Mechanism of action

Mono(ADP)-ribosylation inhibition

Biological functions

Transcriptional regulationImmune response modulationCellular stress responseMicrotubule stability

Disease associations

CancerImmune evasion

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